Endocrine Abstracts

Introduction: Nodular thyroid disease (NTD) is one of the commonest endocrine disease with incidence ranging from 5–30% in various populations Worldwide. They often require surgery for indications such as pressure symptoms or size related reasons. The natural history and etiopathogenesis are largely unclear except in few endemic regions. Immunomodulatory role has often been implicated in their pathogenesis. In this context, we set out study the association between Pro- in...

Introduction: The adenoma – carcinoma sequence in thyroid nodules is a enigmatic phenomenon. There are conflicting reports on development of papillary cancer from benign adenomas. Genomics is the only definitive modality to resolve this hypothesis. Adenomas and papillary carcinomas tend to have mutations in Sodium Iodide symporter gene (NIS) and highly specific BRAF gene respectively. In this context, we set out study the prevalence of these somatic mutations in surgical ...

Introduction: Papillary thyroid carcinoma (PTC) is the commonest endocrine malignancy. Apart from genetic role in its pathogenesis, autoimmunity has been implicated in certain papers. But, reports have been tripolar ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was...